DFFA

Across TCGA patient cohorts, DFFA protein abundance is significantly associated with the RNA expression of many other genes, with 12,339 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DFFA-associated genes across cancer lineages are LZIC, RPL22, and UBIAD1. Each is linked with DFFA in more than 8 cancer types. Because this analysis shows association rather than direction, both DFFA-to-partner and partner-to-DFFA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DFFA versus LZIC in LUAD, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DFFA→partner) and Y-score (partner→DFFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LZIC →	+0.490	+0.234	<.001	<.001	3	9
LUAD	RPL22 →	+0.531	+0.249	<.001	<.001	3	7
BRCA	UBIAD1 →	+0.545	+0.295	<.001	<.001	3	7
PDAC	DNAJC16 →	+0.360	+0.150	<.001	.006	3	6
GBM	CEP104 →	+0.397	+0.290	<.001	<.001	3	6
LUAD	MECR →	+0.442	+0.234	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,339 associations by consensus.

DFFA vs LZIC — LUAD

Explore this scatter interactively →