DFFA

Across TCGA patient cohorts, DFFA mutation is significantly associated with the RNA expression of many other genes, with 450 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DFFA-associated genes across cancer lineages are MTCYBP22, MIR3651, and LINC00351. Each is linked with DFFA in more than 1 cancer types. Because this analysis shows association rather than direction, both DFFA-to-partner and partner-to-DFFA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCYBP22 grouped by DFFA-low versus DFFA-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DFFA→partner) and Y-score (partner→DFFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MTCYBP22 →	+0.244	+3.872	<.001	.008	3	2
BLCA	MIR3651 →	+0.685	+3.851	<.001	.008	3	2
CESC	LINC00351 →	+0.162	+5.201	<.001	.007	3	2
COAD	SOD1P1 →	+0.191	+5.221	<.001	.001	3	1
COAD	UQCRBP2 →	+0.224	+5.321	<.001	.001	3	1
COAD	RPL12P20 →	+0.239	+5.484	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 450 associations by consensus.

MTCYBP22 by DFFA expression — BLCA

Explore this box plot interactively →