DFFA

Across TCGA cell cohorts, DFFA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,707 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DFFA-associated GO terms across cancer lineages are Spindle elongation, Nucleobase biosynthetic process, and DNA-templated DNA replication. Each is linked with DFFA in more than 17 cancer types. Because this analysis shows association rather than direction, both DFFA-to-partner and partner-to-DFFA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle elongation grouped by DFFA-low versus DFFA-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DFFA→partner) and Y-score (partner→DFFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Spindle elongation →	+0.221	+0.974	<.001	<.001	3	18
PANCREAS	Nucleobase biosynthetic process →	+0.156	+1.217	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.131	+1.052	<.001	<.001	3	17
BONE	Transcription initiation at RNA polymerase I promoter →	+0.134	+0.805	.001	.005	2	18
UPPER_AERODIGESTIVE_TRACT	Chromosome segregation →	+0.112	+0.984	.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	Sister chromatid cohesion →	+0.085	+0.949	.005	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,707 associations by consensus.

Spindle elongation by DFFA expression — PANCREAS

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