DESI1

Across TCGA pan-cancer cohorts, DESI1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DESI1 data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DESI1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DESI1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

LUAD, UCEC, and LSCC are the cancer types where DESI1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.437	0.952	<.001	36	view →
UCEC	OS	Median	All	0.978	0.836	.006	10	view →
LSCC	OS	Median	All	0.748	1.000	.006	9	view →
HNSC	OS	Median	All	1.000	0.484	.038	6	view →
PDAC	OS	Tertile	III,IV	0.210	0.781	.024	6	view →
GBM	DFS	Quartile	All	0.242	0.490	.012	2	view →
CCRCC	OS	Median	III,IV	0.808	0.962	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DESI1–LUAD (DFS)

Open the LUAD breakdown →