DESI1

Across TCGA pan-cancer cohorts, DESI1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DESI1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DESI1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DESI1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where DESI1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DESI1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.982	<.001	11	view →
HNSC	Male	III,IV	+0.801	<.001	11	view →
LIHC	All	III,IV	+0.858	<.001	9	view →
READ	All	All	+1.028	<.001	7	view →
LUAD	Female	All	+0.448	<.001	6	view →
THCA	All	All	−0.144	.009	5	view →
LUSC	All	All	+0.238	.002	3	view →
STAD	Male	III,IV	+0.824	.003	2	view →
CHOL	Female	All	+0.493	.006	2	view →
PRAD	All	All	+0.397	<.001	2	view →
KICH	All	All	−0.275	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DESI1–COAD

Open the COAD breakdown →