DESI1

Across TCGA patient cohorts, DESI1 mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DESI1-associated genes across cancer lineages are RNU6-492P, SNORD116-22, and RNA5SP524. Each is linked with DESI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DESI1-to-partner and partner-to-DESI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-492P grouped by DESI1-low versus DESI1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DESI1→partner) and Y-score (partner→DESI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-492P →	+0.353	+7.954	<.001	.008	3	2
SKCM	SNORD116-22 →	+0.677	+5.362	<.001	.005	3	1
HNSC	RNA5SP524 →	+0.323	+7.954	<.001	.008	3	1
HNSC	RN7SKP61 →	+0.144	+7.954	<.001	.008	3	1
SKCM	LINC02433 →	+0.035	+4.979	.009	.009	3	1
SKCM	PSMA5P1 →	+0.109	+6.469	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

RNU6-492P by DESI1 expression — HNSC

Explore this box plot interactively →