DESI1

Across TCGA patient cohorts, DESI1 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DESI1-associated genes across cancer lineages are Astrocytes, NK cells, and CD8+ T-cells. Each is linked with DESI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DESI1-to-partner and partner-to-DESI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Astrocytes grouped by DESI1-low versus DESI1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DESI1→partner) and Y-score (partner→DESI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Astrocytes →	+0.064	+3.825	.014	.041	3	1
STAD	NK cells →	+0.011	+5.597	<.001	.040	3	1
UCEC	CD8+ T-cells →	+0.040	+3.845	<.001	.022	3	1
UCEC	CD8+ Tcm →	+0.039	+3.935	.021	.020	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Astrocytes by DESI1 expression — SKCM

Explore this box plot interactively →