DESI1

Across TCGA cell cohorts, DESI1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,808 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DESI1-associated GO terms across cancer lineages are Positive regulation of T-helper 17 cell lineage commitment, Protein export from nucleus, and Positive regulation of mitochondrial fusion. Each is linked with DESI1 in more than 11 cancer types. Because this analysis shows association rather than direction, both DESI1-to-partner and partner-to-DESI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of T-helper 17 cell lineage commitment grouped by DESI1-low versus DESI1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DESI1→partner) and Y-score (partner→DESI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of T-helper 17 cell lineage commitment →	+0.154	+0.550	.006	.003	3	12
UPPER_AERODIGESTIVE_TRACT	Protein export from nucleus →	+0.132	+0.827	<.001	<.001	3	9
LARGE_INTESTINE	Positive regulation of mitochondrial fusion →	+0.138	+0.709	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Positive regulation of mitochondrial translation →	+0.063	+0.497	<.001	.002	3	8
OVARY	Pigment metabolic process involved in pigmentation →	+0.205	+0.548	.002	.001	3	8
LARGE_INTESTINE	Mitochondrial ribosome assembly →	+0.067	+0.517	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,808 associations by consensus.

Positive regulation of T-helper 17 cell lineage commitment by DESI1 expression — STOMACH

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