DES

Across TCGA patient cohorts, DES protein abundance is significantly associated with the RNA expression of many other genes, with 10,349 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DES-associated genes across cancer lineages are CHRDL1, MEOX2, and CASQ2. Each is linked with DES in more than 7 cancer types. Because this analysis shows association rather than direction, both DES-to-partner and partner-to-DES results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DES versus CHRDL1 in COAD, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DES→partner) and Y-score (partner→DES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CHRDL1 →	+1.697	+1.311	<.001	<.001	3	8
BRCA	MEOX2 →	+1.111	+1.225	<.001	<.001	3	7
HNSC	CASQ2 →	+2.948	+1.914	<.001	<.001	3	7
COAD	LYVE1 →	+1.384	+1.067	<.001	<.001	3	7
HNSC	ITGA7 →	+0.969	+1.642	<.001	<.001	3	7
HNSC	AOX1 →	+1.352	+1.481	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,349 associations by consensus.

DES vs CHRDL1 — COAD

Explore this scatter interactively →