DES

Across TCGA cell cohorts, DES mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DES-associated genes across cancer lineages are GJA8, DBX2, and OR13C8. Each is linked with DES in more than 1 cancer types. Because this analysis shows association rather than direction, both DES-to-partner and partner-to-DES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJA8 grouped by DES-low versus DES-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DES→partner) and Y-score (partner→DES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GJA8 →	+0.594	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	DBX2 →	+0.012	+4.857	.002	.009	3	1
LUNG_NSCLC_LUAD	OR13C8 →	+0.021	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	IL5RA →	+0.042	+4.215	<.001	.002	3	1
STOMACH	GRM6 →	+0.037	+4.794	<.001	.001	3	1
STOMACH	SSX7 →	+0.325	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

GJA8 by DES expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →