DERL2

Across TCGA patient cohorts, DERL2 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. COAD shows the largest number of these associations.

The most reproducible DERL2-associated genes across cancer lineages are RNU4-66P, OR5BE1P, and RNU6-380P. Each is linked with DERL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DERL2-to-partner and partner-to-DERL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-66P grouped by DERL2-low versus DERL2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DERL2→partner) and Y-score (partner→DERL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU4-66P →	+0.289	+7.930	<.001	.008	3	1
LUAD	OR5BE1P →	+0.049	+7.930	<.001	.008	3	1
UCEC	RNU6-380P →	+0.422	+5.885	<.001	.001	3	1
UCEC	RNA5SP113 →	+1.438	+4.641	<.001	.006	3	1
UCEC	TCERG1L-AS1 →	+0.394	+3.911	.002	.007	3	1
UCEC	SNORD62A →	+0.769	+3.993	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

RNU4-66P by DERL2 expression — LUAD

Explore this box plot interactively →