DERL2

Across TCGA pan-cancer cohorts, DERL2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated DERL2 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher DERL2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DERL2 expression acts as an unfavorable survival marker, although some lineages such as OV and BRCA show a favorable association.

UVM, KICH, and LGG are the cancer types where DERL2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.528	0.834	<.001	110	view →
KICH	OS	Tertile	All	0.665	1.000	.003	57	view →
LGG	OS	Median	All	0.747	0.878	<.001	47	view →
ACC	DFS	Quartile	All	0.292	0.791	.001	41	view →
CHOL	DFS	Tertile	All	0.119	0.761	<.001	31	view →
OV	OS	Tertile	II,III,IV	0.427	0.317	.010	30	view →
BRCA	DFS	Median	IV	0.770	0.328	.003	29	view →
LIHC	OS	Quartile	All	0.674	0.856	.005	26	view →
LUAD	DFS	Median	II,III,IV	0.311	0.566	.001	24	view →
BLCA	DFS	Quartile	All	0.372	0.648	.012	22	view →
UCEC	DFS	Median	III,IV	0.657	0.484	.027	20	view →
ESCA	DFS	Tertile	All	1.000	0.419	.009	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

DERL2–UVM (OS)

Open the UVM breakdown →