DERL2

Across TCGA cell cohorts, DERL2 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DERL2-associated genes across cancer lineages are AVP, IL36B, and KRTAP4-1. Each is linked with DERL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DERL2-to-partner and partner-to-DERL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by DERL2-low versus DERL2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DERL2→partner) and Y-score (partner→DERL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	IL36B →	+0.021	+5.209	.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.151	+4.867	<.001	.009	3	1
LARGE_INTESTINE	SH3GL2 →	+1.289	+3.474	<.001	.003	3	1
LARGE_INTESTINE	PCCB →	+0.657	+3.125	.001	.008	3	1
LARGE_INTESTINE	MRO →	+0.211	+3.215	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

AVP by DERL2 expression — BLOOD_Lymphoma

Explore this box plot interactively →