DEPP1

Across TCGA patient cohorts, DEPP1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEPP1-associated genes across cancer lineages are Notch1, STAT3_pY705, and c-Met_pY1235. Each is linked with DEPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEPP1-to-partner and partner-to-DEPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DEPP1-low versus DEPP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPP1→partner) and Y-score (partner→DEPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.163	+2.820	.045	.035	3	1
UCEC	STAT3_pY705 →	-0.299	-3.000	.049	.037	3	1
UCEC	c-Met_pY1235 →	+0.092	+2.817	.032	.036	3	1
UCEC	ACC1 →	+0.497	+3.000	.018	.037	2	1
UCEC	A-Raf_pS299 →	-0.146	-3.000	.035	.037	1	1
UCEC	Rad50 →	-0.335	-3.000	.017	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Notch1 by DEPP1 expression — UCEC

Explore this box plot interactively →