DEPP1

Across TCGA pan-cancer cohorts, DEPP1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of DEPP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DEPP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DEPP1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, LUSC, and LUAD are the cancer types where DEPP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEPP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.686	<.001	11	view →
LUSC	Female	II,III,IV	−2.561	<.001	8	view →
LUAD	All	All	−1.055	<.001	7	view →
BRCA	All	III,IV	−2.306	<.001	6	view →
UCEC	All	All	−1.994	<.001	6	view →
STAD	All	II,III,IV	+0.948	.004	6	view →
COAD	All	II,III,IV	+0.657	.013	3	view →
CHOL	All	All	+1.501	.017	2	view →
KICH	Female	All	−1.128	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

DEPP1–KIRC

Open the KIRC breakdown →