DEPP1

Across TCGA cell cohorts, DEPP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,195 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible DEPP1-associated GO terms across cancer lineages are Regulation of proteolysis, Protein localization to endoplasmic reticulum, and Maintenance of protein localization in organelle. Each is linked with DEPP1 in more than 11 cancer types. Because this analysis shows association rather than direction, both DEPP1-to-partner and partner-to-DEPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of proteolysis grouped by DEPP1-low versus DEPP1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPP1→partner) and Y-score (partner→DEPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of proteolysis →	+0.089	+2.527	.001	<.001	3	12
PANCREAS	Protein localization to endoplasmic reticulum →	+0.143	+2.578	<.001	<.001	3	12
PANCREAS	Maintenance of protein localization in organelle →	+0.133	+2.603	<.001	<.001	3	12
SOFT_TISSUE	Intracellular receptor signaling pathway →	+0.043	+2.095	.006	<.001	2	12
SOFT_TISSUE	Maintenance of protein location in cell →	+0.093	+1.450	<.001	<.001	3	11
KIDNEY	Regulation of tumor necrosis factor production →	+0.101	+3.222	.004	.005	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,195 associations by consensus.

Regulation of proteolysis by DEPP1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →