DEPDC7

Across TCGA cell cohorts, DEPDC7 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible DEPDC7-associated genes across cancer lineages are TPH2, KRTAP5-4, and IL3. Each is linked with DEPDC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEPDC7-to-partner and partner-to-DEPDC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPH2 grouped by DEPDC7-low versus DEPDC7-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPDC7→partner) and Y-score (partner→DEPDC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TPH2 →	+0.042	+3.823	.008	.006	3	1
SKIN	KRTAP5-4 →	+0.073	+4.562	<.001	<.001	3	1
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_SCLC	OR4X2 →	+0.038	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+1.180	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF17 →	+0.013	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

TPH2 by DEPDC7 expression — SKIN

Explore this box plot interactively →