DEPDC5

Across TCGA patient cohorts, DEPDC5 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,769 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DEPDC5-associated proteins across cancer lineages are XRCC5, XRCC6, and SIN3A. Each is linked with DEPDC5 in more than 5 cancer types. Because this analysis shows association rather than direction, both DEPDC5-to-partner and partner-to-DEPDC5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DEPDC5 versus XRCC5 in GBM, with a Pearson correlation of 0.58.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPDC5→partner) and Y-score (partner→DEPDC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	XRCC5 →	+0.236	+0.375	<.001	<.001	3	6
GBM	XRCC6 →	+0.274	+0.379	<.001	<.001	3	5
GBM	SIN3A →	+0.274	+0.365	.002	<.001	3	5
GBM	SMC1A →	+0.392	+0.418	<.001	<.001	3	5
GBM	SF3A3 →	+0.283	+0.438	<.001	<.001	3	4
LSCC	SMU1 →	+0.221	+0.348	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,769 associations by consensus.

DEPDC5 vs XRCC5 — GBM

Explore this scatter interactively →