DEPDC5

Across TCGA patient cohorts, DEPDC5 mutation is significantly associated with the RNA expression of many other genes, with 6,964 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEPDC5-associated genes across cancer lineages are MTFP1, TRAIP, and TSPY26P. Each is linked with DEPDC5 in more than 4 cancer types. Because this analysis shows association rather than direction, both DEPDC5-to-partner and partner-to-DEPDC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTFP1 grouped by DEPDC5-low versus DEPDC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPDC5→partner) and Y-score (partner→DEPDC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTFP1 →	+0.447	+2.818	<.001	<.001	3	5
UCEC	TRAIP →	+0.372	+2.024	.004	.001	3	4
STAD	TSPY26P →	-0.833	-3.700	.002	.001	3	4
UCEC	WDR76 →	+0.905	+2.947	<.001	<.001	3	4
UCEC	PBK →	+1.121	+2.936	<.001	<.001	3	4
UCEC	PIMREG →	+0.933	+2.384	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,964 associations by consensus.

MTFP1 by DEPDC5 expression — UCEC

Explore this box plot interactively →