DEPDC5

Across TCGA cell cohorts, DEPDC5 mutation is significantly associated with the RNA expression of many other genes, with 1,458 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DEPDC5-associated genes across cancer lineages are PPM1A, GUCA1B, and ENPP5. Each is linked with DEPDC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEPDC5-to-partner and partner-to-DEPDC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPM1A grouped by DEPDC5-low versus DEPDC5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPDC5→partner) and Y-score (partner→DEPDC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPM1A →	+0.405	+2.043	.007	.008	3	2
LARGE_INTESTINE	GUCA1B →	+0.740	+3.169	.004	.009	3	2
LARGE_INTESTINE	ENPP5 →	+0.727	+2.043	.004	.008	3	2
LARGE_INTESTINE	GCH1 →	+0.609	+2.743	<.001	.001	3	2
LARGE_INTESTINE	OSBPL11 →	+0.511	+2.043	<.001	.008	3	2
LARGE_INTESTINE	PPP2R5E →	+0.684	+3.491	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,458 associations by consensus.

PPM1A by DEPDC5 expression — LARGE_INTESTINE

Explore this box plot interactively →