DEPDC4

Across TCGA patient cohorts, DEPDC4 mutation is significantly associated with the RNA expression of many other genes, with 572 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEPDC4-associated genes across cancer lineages are RN7SL228P, SEPTIN14P17, and MIR6078. Each is linked with DEPDC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both DEPDC4-to-partner and partner-to-DEPDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL228P grouped by DEPDC4-low versus DEPDC4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPDC4→partner) and Y-score (partner→DEPDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL228P →	+0.069	+4.186	<.001	.007	3	3
HNSC	SEPTIN14P17 →	+0.163	+5.124	.008	.008	3	3
BRCA	MIR6078 →	+0.658	+6.016	<.001	.002	3	2
SKCM	OR52X1P →	+0.043	+3.775	<.001	<.001	3	2
SKCM	MTND6P14 →	+0.029	+4.186	<.001	.007	3	2
SKCM	NDUFA5P8 →	+0.067	+4.678	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 572 associations by consensus.

RN7SL228P by DEPDC4 expression — SKCM

Explore this box plot interactively →