DEPDC4

Across TCGA pan-cancer cohorts, DEPDC4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DEPDC4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DEPDC4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DEPDC4 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, KICH, and KIRC are the cancer types where DEPDC4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEPDC4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.346	<.001	11	view →
KICH	Female	II,III,IV	−1.042	<.001	10	view →
KIRC	Female	All	−0.382	<.001	10	view →
LUAD	Male	All	+0.414	<.001	9	view →
THCA	Male	All	−0.298	<.001	9	view →
LUSC	Female	All	+0.635	<.001	8	view →
BLCA	All	III,IV	+0.457	<.001	8	view →
LIHC	Male	All	+0.281	<.001	8	view →
CHOL	All	All	+0.381	.001	2	view →
UCEC	All	All	+0.239	.022	2	view →
COAD	Male	All	+0.196	.018	2	view →
PRAD	All	All	+0.170	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DEPDC4–HNSC

Open the HNSC breakdown →