DEPDC4

Across TCGA patient cohorts, DEPDC4 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEPDC4-associated genes across cancer lineages are ASNS, eIF4E, and JNK2. Each is linked with DEPDC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both DEPDC4-to-partner and partner-to-DEPDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by DEPDC4-low versus DEPDC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPDC4→partner) and Y-score (partner→DEPDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.587	+3.321	<.001	.010	3	4
UCEC	eIF4E →	+0.186	+3.013	.043	.018	3	1
UCEC	JNK2 →	+0.222	+2.115	.010	.019	3	1
UCEC	Ku80 →	+0.276	+2.128	.007	.010	3	1
UCEC	p62 Lck ligand →	+0.367	+2.179	.009	.034	3	1
UCEC	PRAS40_pT246 →	+0.185	+2.128	.013	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ASNS by DEPDC4 expression — UCEC

Explore this box plot interactively →