DEPDC4

Across TCGA cell cohorts, DEPDC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,018 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DEPDC4-associated GO terms across cancer lineages are Positive regulation of centriole replication, Positive regulation of DNA biosynthetic process, and Protein localization to heterochromatin. Each is linked with DEPDC4 in more than 11 cancer types. Because this analysis shows association rather than direction, both DEPDC4-to-partner and partner-to-DEPDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of centriole replication grouped by DEPDC4-low versus DEPDC4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPDC4→partner) and Y-score (partner→DEPDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of centriole replication →	+0.094	+0.510	<.001	<.001	3	12
SOFT_TISSUE	Positive regulation of DNA biosynthetic process →	+0.085	+0.744	<.001	<.001	3	11
OVARY	Protein localization to heterochromatin →	+0.124	+0.679	<.001	<.001	3	11
SOFT_TISSUE	Regulation of cell cycle G2/M phase transition →	+0.063	+0.875	<.001	<.001	3	11
OESOPHAGUS	Negative regulation of cell cycle G2/M phase transition →	+0.066	+0.613	.004	.004	3	11
BREAST	Negative regulation of double-strand break repair →	+0.061	+0.479	<.001	.009	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,018 associations by consensus.

Positive regulation of centriole replication by DEPDC4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →