DEPDC4

Across TCGA cell cohorts, DEPDC4 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DEPDC4-associated genes across cancer lineages are HSFY1, MOS, and OOSP2. Each is linked with DEPDC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEPDC4-to-partner and partner-to-DEPDC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY1 grouped by DEPDC4-low versus DEPDC4-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPDC4→partner) and Y-score (partner→DEPDC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	HSFY1 →	+0.026	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	MOS →	+0.448	+4.736	<.001	.009	3	1
LARGE_INTESTINE	OOSP2 →	+0.016	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR9Q2 →	+0.062	+4.977	<.001	.007	3	1
LARGE_INTESTINE	SLC15A5 →	+0.023	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

HSFY1 by DEPDC4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →