DEPDC1B

Across TCGA patient cohorts, DEPDC1B mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEPDC1B-associated genes across cancer lineages are Caspase-7-cleavedD198, c-Met_pY1235, and EGFR_pY1068. Each is linked with DEPDC1B in more than 1 cancer types. Because this analysis shows association rather than direction, both DEPDC1B-to-partner and partner-to-DEPDC1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DEPDC1B-low versus DEPDC1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPDC1B→partner) and Y-score (partner→DEPDC1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.515	+1.700	.014	.040	3	2
UCEC	c-Met_pY1235 →	+0.053	+1.424	.044	.027	3	2
UCEC	EGFR_pY1068 →	-0.217	-1.662	.014	.011	3	1
UCEC	INPP4B →	-0.254	-2.700	.026	.005	3	1
UCEC	Ku80 →	+0.252	+2.013	.002	.001	3	1
UCEC	MEK1 →	+0.360	+2.321	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Caspase-7-cleavedD198 by DEPDC1B expression — UCEC

Explore this box plot interactively →