DEPDC1B

Across TCGA pan-cancer cohorts, DEPDC1B RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated DEPDC1B data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DEPDC1B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DEPDC1B expression acts as an unfavorable survival marker, although some lineages such as READ and COAD show a favorable association.

KIRP, MESO, and KICH are the cancer types where DEPDC1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.853	0.959	<.001	132	view →
MESO	OS	Median	All	0.393	0.686	<.001	123	view →
KICH	OS	Quartile	II,III,IV	0.306	1.000	<.001	107	view →
UVM	DFS	Quartile	All	0.270	0.895	<.001	100	view →
LIHC	DFS	Median	All	0.375	0.491	<.001	100	view →
ACC	OS	Median	All	0.402	0.806	<.001	89	view →
LUAD	OS	Median	All	0.254	0.483	<.001	84	view →
PAAD	OS	Median	All	0.512	0.707	<.001	64	view →
LGG	OS	Median	All	0.374	0.529	<.001	54	view →
KIRC	DFS	Quartile	All	0.478	0.692	.001	42	view →
CESC	DFS	Tertile	III,IV	0.487	0.880	.001	40	view →
SARC	DFS	Quartile	All	0.516	0.756	<.001	32	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

DEPDC1B–KIRP (DFS)

Open the KIRP breakdown →