DEPDC1B

Across TCGA cell cohorts, DEPDC1B mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DEPDC1B-associated genes across cancer lineages are KRT82, GPX5, and KRTAP4-2. Each is linked with DEPDC1B in more than 1 cancer types. Because this analysis shows association rather than direction, both DEPDC1B-to-partner and partner-to-DEPDC1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT82 grouped by DEPDC1B-low versus DEPDC1B-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPDC1B→partner) and Y-score (partner→DEPDC1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRT82 →	+0.046	+5.643	<.001	.002	3	2
PANCREAS	GPX5 →	+0.033	+5.000	<.001	.006	3	1
PANCREAS	KRTAP4-2 →	+0.045	+5.000	<.001	.006	3	1
SOFT_TISSUE	OR11H6 →	+0.039	+4.930	<.001	.008	3	1
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	1
BLOOD_Lymphoma	FTHL17 →	+0.180	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

KRT82 by DEPDC1B expression — BLOOD_Lymphoma

Explore this box plot interactively →