DEPDC1

Across TCGA patient cohorts, DEPDC1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DEPDC1-associated genes across cancer lineages are Ku80, p38-MAPK_pT180_Y182, and Caspase-7-cleavedD198. Each is linked with DEPDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEPDC1-to-partner and partner-to-DEPDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by DEPDC1-low versus DEPDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPDC1→partner) and Y-score (partner→DEPDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.159	+1.083	.035	.041	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.300	-2.087	.037	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.630	+1.926	<.001	.008	3	2
UCEC	c-Jun_pS73 →	-0.105	-2.077	.038	.005	3	2
UCEC	4E-BP1 →	+0.251	+2.444	.003	.001	3	2
UCEC	C-Raf →	+0.107	+1.502	.019	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Ku80 by DEPDC1 expression — UCEC

Explore this box plot interactively →