DEPDC1

Across TCGA pan-cancer cohorts, DEPDC1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DEPDC1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DEPDC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DEPDC1 is over-expressed in tumor.

HNSC, LUAD, and BLCA are the cancer types where DEPDC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DEPDC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.622	<.001	12	view →
LUAD	Male	III,IV	+2.690	<.001	11	view →
BLCA	All	IV	+2.391	<.001	11	view →
KIRP	All	III,IV	+1.148	<.001	11	view →
KIRC	Male	IV	+1.109	<.001	11	view →
LIHC	Male	All	+1.523	<.001	9	view →
LUSC	Male	III,IV	+3.060	<.001	8	view →
STAD	All	II,III,IV	+1.946	<.001	8	view →
COAD	All	II,III,IV	+0.769	<.001	7	view →
UCEC	All	II,III,IV	+2.973	<.001	6	view →
BRCA	All	II,III,IV	+2.211	<.001	6	view →
CHOL	Male	All	+2.651	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DEPDC1–HNSC

Open the HNSC breakdown →