DEPDC1

Across TCGA cell cohorts, DEPDC1 mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DEPDC1-associated genes across cancer lineages are OR56A4, VSTM2B, and TAS2R39. Each is linked with DEPDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEPDC1-to-partner and partner-to-DEPDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A4 grouped by DEPDC1-low versus DEPDC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEPDC1→partner) and Y-score (partner→DEPDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR56A4 →	+0.007	+3.289	<.001	.009	3	2
BLOOD_Leukemia	VSTM2B →	+0.065	+3.289	<.001	.009	3	1
BLOOD_Leukemia	TAS2R39 →	+0.084	+4.661	<.001	<.001	3	1
BLOOD_Leukemia	HNRNPCL3 →	+0.036	+3.289	<.001	.009	3	1
LARGE_INTESTINE	GPR63 →	+0.693	+3.169	.001	.009	3	1
LARGE_INTESTINE	BNIP1 →	+0.484	+3.237	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

OR56A4 by DEPDC1 expression — BLOOD_Leukemia

Explore this box plot interactively →