Across TCGA patient cohorts, DENND6B RNA expression is significantly associated with the protein abundance of many other proteins, with 10,010 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DENND6B-associated proteins across cancer lineages are SBF1, BBS1, and BBS7. Each is linked with DENND6B in more than 4 cancer types. Because this analysis shows association rather than direction, both DENND6B-to-partner and partner-to-DENND6B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND6B→partner) and Y-score (partner→DENND6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SBF1 →	+0.294	+0.882	.002	<.001	3	4
BRCA	BBS1 →	+0.752	+0.719	<.001	<.001	3	4
BRCA	BBS7 →	+0.319	+0.511	<.001	.001	3	4
LUAD	TRIOBP →	+0.279	+0.519	<.001	<.001	3	4
OV	CETN2 →	+0.371	+0.668	.003	.004	3	4
UCEC	DYNC2H1 →	+0.433	+0.536	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,010 associations by consensus.

Exploration

DENND6B survival (RNA) · tumor vs normal (RNA) · all DENND6B data types