Across TCGA patient cohorts, DENND6B protein abundance is significantly associated with the RNA expression of many other genes, with 1,330 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DENND6B-associated genes across cancer lineages are CBY1, ACO2, and ZNRF3. Each is linked with DENND6B in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND6B-to-partner and partner-to-DENND6B results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND6B→partner) and Y-score (partner→DENND6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CBY1 →	+0.981	+0.824	<.001	.002	3	2
BRCA	ACO2 →	+1.103	+0.684	.001	.002	3	2
BRCA	ZNRF3 →	+1.477	+0.973	.002	.006	3	2
BRCA	EFCAB6 →	+1.430	+0.719	<.001	.006	3	2
BRCA	NSF →	+1.101	+0.769	.006	.005	3	2
GBM	CRISPLD2 →	-1.055	-0.768	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,330 associations by consensus.

Exploration

DENND6B survival (RNA) · tumor vs normal (RNA) · all DENND6B data types