Across TCGA patient cohorts, DENND6B mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND6B-associated genes across cancer lineages are ATM, MSH2, and PDCD4. Each is linked with DENND6B in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND6B-to-partner and partner-to-DENND6B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND6B→partner) and Y-score (partner→DENND6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.485	-2.000	.017	.032	3	2
UCEC	MSH2 →	-0.331	-3.143	.001	.018	3	1
UCEC	PDCD4 →	-0.508	-2.700	.016	.006	3	1
UCEC	Chk2 →	-0.214	-2.000	.043	.032	3	1
UCEC	Annexin-1 →	+0.812	+2.700	<.001	.006	2	1
UCEC	Cyclin-B1 →	+0.561	+2.000	.026	.032	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

DENND6B survival (RNA) · tumor vs normal (RNA) · all DENND6B data types