Across TCGA cell cohorts, DENND6B mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DENND6B-associated genes across cancer lineages are PRLHR, MYPN, and CX3CR1. Each is linked with DENND6B in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND6B-to-partner and partner-to-DENND6B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND6B→partner) and Y-score (partner→DENND6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRLHR →	+0.010	+5.247	<.001	.001	3	1
BLOOD_Leukemia	MYPN →	+0.021	+4.152	.001	.009	3	1
SKIN	CX3CR1 →	+0.049	+3.793	.001	.007	3	1
SKIN	SNTN →	+0.047	+4.196	<.001	.002	3	1
SKIN	PRRT1B →	+0.040	+4.054	<.001	.004	3	1
LARGE_INTESTINE	MT1G →	+3.524	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

DENND6B survival (RNA) · tumor vs normal (RNA) · all DENND6B data types