DENND6A

Across TCGA patient cohorts, DENND6A mutation is significantly associated with the RNA expression of many other genes, with 2,224 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND6A-associated genes across cancer lineages are DPY19L4P2, GUSBP12, and FAM230D. Each is linked with DENND6A in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND6A-to-partner and partner-to-DENND6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPY19L4P2 grouped by DENND6A-low versus DENND6A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND6A→partner) and Y-score (partner→DENND6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DPY19L4P2 →	+0.196	+4.017	<.001	.003	3	3
ACC	GUSBP12 →	+0.146	+5.228	<.001	.005	3	2
ACC	FAM230D →	+0.084	+4.887	<.001	.009	3	2
ACC	EGFLAM-AS2 →	+0.157	+5.228	<.001	.005	3	2
CESC	RNU6-1308P →	+0.207	+4.559	.008	.006	3	2
BLCA	PSMA2P1 →	+0.163	+3.931	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,224 associations by consensus.

DPY19L4P2 by DENND6A expression — COAD

Explore this box plot interactively →