DENND6A-AS1

Across TCGA pan-cancer cohorts, DENND6A-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated DENND6A-AS1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher DENND6A-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated DENND6A-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

SKCM, BLCA, and KIRC are the cancer types where DENND6A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.688	0.552	<.001	94	view →
BLCA	DFS	Tertile	All	0.466	0.226	<.001	66	view →
KIRC	DFS	Quartile	IV	0.243	0.758	.001	57	view →
OV	DFS	Quartile	II,III,IV	0.470	0.350	.008	34	view →
ACC	DFS	Median	All	0.281	0.640	.002	19	view →
MESO	DFS	Quartile	III,IV	0.503	0.277	.004	15	view →
THCA	DFS	Quartile	IV	0.478	1.000	.025	10	view →
LUSC	OS	Tertile	All	0.722	0.623	.014	6	view →
CHOL	DFS	Quartile	III,IV	1.000	0.174	.040	3	view →
KIRP	OS	Median	II,III,IV	0.844	0.627	.020	3	view →
ESCA	DFS	Quartile	III,IV	0.664	0.248	.036	3	view →
SARC	OS	Median	All	0.766	0.935	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

DENND6A-AS1–SKCM (DFS)

Open the SKCM breakdown →