DENND6A-AS1

Across TCGA pan-cancer cohorts, DENND6A-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of DENND6A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where DENND6A-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types DENND6A-AS1 is over-expressed in tumor, although a few such as UCEC and BLCA show the opposite, repressed pattern.

UCEC, BLCA, and LUSC are the cancer types where DENND6A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DENND6A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	−0.464	<.001	6	view →
BLCA	All	All	−0.403	.002	6	view →
LUSC	All	II,III,IV	−0.294	<.001	6	view →
HNSC	All	III,IV	−0.196	.008	5	view →
LUAD	All	III,IV	−0.412	<.001	4	view →
LIHC	All	All	+0.103	.002	4	view →
BRCA	Female	All	−0.195	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

DENND6A-AS1–UCEC

Open the UCEC breakdown →