DENND5B

Across TCGA patient cohorts, DENND5B protein abundance is significantly associated with the RNA expression of many other genes, with 1,740 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DENND5B-associated genes across cancer lineages are AFAP1L2, MT1A, and IGLV1-44. Each is linked with DENND5B in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND5B-to-partner and partner-to-DENND5B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND5B versus AFAP1L2 in OV, with a Pearson correlation of -0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND5B→partner) and Y-score (partner→DENND5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AFAP1L2 →	-2.944	-0.608	<.001	.008	3	2
LUAD	MT1A →	+1.776	+0.414	.001	.009	3	2
LSCC	IGLV1-44 →	+1.107	+0.202	.003	.008	3	2
LSCC	IGHV3-38 →	+0.741	+0.307	.005	.006	3	2
LSCC	NPAP1P6 →	+0.205	+0.294	<.001	.004	3	2
CCRCC	RAMP1 →	+1.528	+0.398	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,740 associations by consensus.

DENND5B vs AFAP1L2 — OV

Explore this scatter interactively →