DENND4C

Across TCGA pan-cancer cohorts, DENND4C mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DENND4C data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher DENND4C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DENND4C expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

OV, LSCC, and CCRCC are the cancer types where DENND4C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Quartile	All	0.654	1.000	.049	8	view →
LSCC	OS	Quartile	II,III,IV	0.800	0.964	.030	6	view →
CCRCC	DFS	Tertile	II,III,IV	0.915	0.399	.040	5	view →
HNSC	DFS	Tertile	III,IV	0.760	0.496	.023	3	view →
UCEC	DFS	Tertile	II,III,IV	0.761	1.000	.048	2	view →
LUAD	OS	Quartile	II,III,IV	0.261	0.687	.010	2	view →
PDAC	OS	Quartile	III,IV	0.281	0.522	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DENND4C–OV (DFS)

Open the OV breakdown →