DENND4A

Across TCGA pan-cancer cohorts, DENND4A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DENND4A data layer compared with 20 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DENND4A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DENND4A expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

HNSC, PDAC, and GBM are the cancer types where DENND4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.176	0.964	.017	12	view →
PDAC	DFS	Tertile	IV	0.550	0.217	.024	6	view →
GBM	OS	Tertile	All	0.859	0.924	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DENND4A–HNSC (OS)

Open the HNSC breakdown →