DENND4A

Across TCGA patient cohorts, DENND4A RNA expression is significantly associated with the protein abundance of many other proteins, with 13,311 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DENND4A-associated proteins across cancer lineages are LRPPRC, POLDIP2, and ZC3HC1_S24. Each is linked with DENND4A in more than 6 cancer types. Because this analysis shows association rather than direction, both DENND4A-to-partner and partner-to-DENND4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND4A versus LRPPRC in OV, with a Pearson correlation of -0.47.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4A→partner) and Y-score (partner→DENND4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LRPPRC →	-0.521	-0.742	<.001	<.001	3	7
OV	POLDIP2 →	-0.245	-0.551	.005	.006	3	5
BRCA	ZC3HC1_S24 →	-0.696	-0.487	<.001	<.001	3	5
LSCC	DENND4A_S1240 →	+0.446	+0.421	<.001	<.001	3	5
BRCA	HDGFL3 →	+0.741	+0.530	<.001	.001	3	5
OV	MRPL32 →	-0.416	-0.682	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,311 associations by consensus.

DENND4A vs LRPPRC — OV

Explore this scatter interactively →