DENND4A

Across TCGA patient cohorts, DENND4A mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND4A-associated genes across cancer lineages are eEF2, Caspase-7-cleavedD198, and ASNS. Each is linked with DENND4A in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND4A-to-partner and partner-to-DENND4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DENND4A-low versus DENND4A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4A→partner) and Y-score (partner→DENND4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eEF2 →	+0.324	+3.000	.038	.036	3	3
COAD	Caspase-7-cleavedD198 →	+1.557	+3.593	<.001	.001	3	3
UCEC	ASNS →	+0.356	+1.643	<.001	.002	3	3
UCEC	4E-BP1 →	+0.265	+2.169	<.001	.002	3	3
SKCM	Caveolin-1 →	-0.619	-3.169	.021	.017	3	3
SKCM	CD49b →	+0.278	+2.132	.006	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

eEF2 by DENND4A expression — STAD

Explore this box plot interactively →