DENND4A

Across TCGA cell cohorts, DENND4A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,252 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DENND4A-associated GO terms across cancer lineages are Regulation of Rab protein signal transduction, Circadian sleep/wake cycle, and Establishment of protein localization to vacuole. Each is linked with DENND4A in more than 16 cancer types. Because this analysis shows association rather than direction, both DENND4A-to-partner and partner-to-DENND4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of Rab protein signal transduction grouped by DENND4A-low versus DENND4A-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4A→partner) and Y-score (partner→DENND4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of Rab protein signal transduction →	+0.115	+0.922	<.001	<.001	3	17
LIVER	Circadian sleep/wake cycle →	+0.182	+1.118	.001	<.001	3	12
LUNG_NSCLC_LUSC	Establishment of protein localization to vacuole →	+0.062	+0.648	.001	.004	3	10
OESOPHAGUS	Negative regulation of hematopoietic stem cell differentiation →	+0.154	+0.854	<.001	<.001	3	9
OESOPHAGUS	Post-Golgi vesicle-mediated transport →	+0.065	+0.665	<.001	.009	3	9
BREAST	Intracellular magnesium ion homeostasis →	+0.102	+0.449	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,252 associations by consensus.

Regulation of Rab protein signal transduction by DENND4A expression — OESOPHAGUS

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