DENND4A

Across TCGA cell cohorts, DENND4A mutation is significantly associated with the RNA expression of many other genes, with 1,243 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DENND4A-associated genes across cancer lineages are CCR8, ZNF574, and GAR1. Each is linked with DENND4A in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND4A-to-partner and partner-to-DENND4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCR8 grouped by DENND4A-low versus DENND4A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND4A→partner) and Y-score (partner→DENND4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CCR8 →	+0.043	+4.321	<.001	.002	3	2
LARGE_INTESTINE	ZNF574 →	+0.423	+3.321	.002	.003	3	2
LARGE_INTESTINE	GAR1 →	+0.455	+2.350	.001	.008	3	2
LARGE_INTESTINE	NOP2 →	+0.494	+2.458	.003	<.001	3	2
BLOOD_Leukemia	CENPVL1 →	+0.196	+3.234	.008	.008	3	2
LARGE_INTESTINE	TTPA →	+0.761	+1.949	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,243 associations by consensus.

CCR8 by DENND4A expression — CNS

Explore this box plot interactively →