DENND3

Across TCGA cell cohorts, DENND3 mutation is significantly associated with the RNA expression of many other genes, with 789 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DENND3-associated genes across cancer lineages are TRPM5, EXOC1L, and MIOX. Each is linked with DENND3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DENND3-to-partner and partner-to-DENND3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRPM5 grouped by DENND3-low versus DENND3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND3→partner) and Y-score (partner→DENND3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TRPM5 →	+0.301	+4.417	.001	<.001	3	3
LUNG_NSCLC_LUSC	EXOC1L →	+0.063	+4.643	<.001	.008	3	2
LARGE_INTESTINE	MIOX →	+0.236	+2.115	.002	.004	3	2
LARGE_INTESTINE	UBE2D3 →	+0.538	+3.389	<.001	.001	3	2
LARGE_INTESTINE	FAM149A →	+1.067	+2.628	.003	.002	3	2
LARGE_INTESTINE	TRIM23 →	+0.613	+2.628	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 789 associations by consensus.

TRPM5 by DENND3 expression — OVARY

Explore this box plot interactively →