DENND2D

Across TCGA patient cohorts, DENND2D mutation is significantly associated with the RNA expression of many other genes, with 468 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DENND2D-associated genes across cancer lineages are MIR4727, REEP4, and TYMSOS. Each is linked with DENND2D in more than 1 cancer types. Because this analysis shows association rather than direction, both DENND2D-to-partner and partner-to-DENND2D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4727 grouped by DENND2D-low versus DENND2D-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2D→partner) and Y-score (partner→DENND2D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4727 →	+0.613	+5.203	.002	.007	3	2
UCEC	REEP4 →	+0.489	+3.721	.004	<.001	3	2
UCEC	TYMSOS →	+0.804	+3.733	<.001	<.001	3	2
COAD	RNU6-147P →	+0.394	+3.476	<.001	.005	3	2
CESC	AMZ2P3 →	+0.102	+7.164	<.001	<.001	3	2
CESC	OR12D2 →	+0.052	+5.418	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 468 associations by consensus.

MIR4727 by DENND2D expression — BRCA

Explore this box plot interactively →