DENND2B

Across TCGA pan-cancer cohorts, DENND2B mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of DENND2B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DENND2B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DENND2B is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, PDAC, and LSCC are the cancer types where DENND2B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DENND2B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.795	<.001	11	view →
PDAC	Female	All	+0.468	<.001	8	view →
LSCC	All	All	−0.121	.001	6	view →
OV	All	All	−0.598	.001	2	view →
HNSC	All	IV	−0.175	.019	2	view →
LUAD	Male	All	−0.110	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

DENND2B–COAD

Open the COAD breakdown →