DENND2B

Across TCGA pan-cancer cohorts, DENND2B RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated DENND2B data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher DENND2B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated DENND2B expression acts as an unfavorable survival marker, although some lineages such as ESCA and LUAD show a favorable association.

ESCA, LUSC, and LGG are the cancer types where DENND2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Quartile	II,III,IV	0.566	0.250	.006	43	view →
LUSC	DFS	Tertile	All	0.718	0.822	.004	30	view →
LGG	DFS	Tertile	All	0.767	0.890	.001	29	view →
LIHC	DFS	Median	II,III,IV	0.251	0.405	.007	27	view →
LUAD	DFS	Median	III,IV	0.759	0.527	.009	27	view →
CESC	DFS	Tertile	III,IV	0.366	0.782	.005	26	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
MESO	OS	Median	All	0.442	0.636	.001	24	view →
SARC	OS	Tertile	All	0.925	0.677	<.001	21	view →
ACC	DFS	Tertile	All	0.316	0.912	.005	17	view →
HNSC	DFS	Median	IV	0.731	0.600	.008	15	view →
OV	OS	Tertile	III,IV	0.282	0.381	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

DENND2B–ESCA (DFS)

Open the ESCA breakdown →