DENND2B

Across TCGA patient cohorts, DENND2B RNA expression is significantly associated with the protein abundance of many other proteins, with 11,263 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible DENND2B-associated proteins across cancer lineages are DENND2B_S105, DENND2B_S368, and RIC8A. Each is linked with DENND2B in more than 7 cancer types. Because this analysis shows association rather than direction, both DENND2B-to-partner and partner-to-DENND2B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DENND2B versus DENND2B_S105 in LSCC, with a Pearson correlation of 0.52.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DENND2B→partner) and Y-score (partner→DENND2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DENND2B_S105 →	+0.635	+0.576	<.001	<.001	3	8
GBM	DENND2B_S368 →	+0.796	+0.566	<.001	<.001	3	6
HNSC	RIC8A →	+0.184	+0.433	<.001	<.001	3	5
BRCA	SERPINH1 →	+0.404	+0.486	<.001	<.001	3	5
BRCA	LGALS1 →	+0.432	+0.606	<.001	<.001	3	5
BRCA	ANTXR1 →	+0.658	+0.683	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,263 associations by consensus.

DENND2B vs DENND2B_S105 — LSCC

Explore this scatter interactively →